Do you sometimes need to be a little more business-like? Go for just the facts–always including more than one way for people to get a hold of you.
Are there people you correspond with that will appreciate the addition of one of your images in each email they receive? Not everyone likes these attachments, but they can be fun.
Do friends and family want to see a more personalized closing? I just thought of this! And now I’m creating a signature block for family: "Your darling daughter, wife, sister, or cousin . . . If you’re missing me madly, check out my blog to see what I’m up to: . . . " Love it. And so much more personal than my biz signature. I’m going to include a tiny, fun pic of myself and try to remember to change it often.
Do you wear multiple hats? One email might include a signature about your Web design business while another is about your fine art.
Related: Info about creating signature blocks in various email programs.